{"id":7690,"date":"2023-09-25T10:43:12","date_gmt":"2023-09-25T08:43:12","guid":{"rendered":"https:\/\/tam-plenus.ch\/blog-spermidin-gegen-demenz\/"},"modified":"2025-10-20T15:43:33","modified_gmt":"2025-10-20T13:43:33","slug":"spermidin-gegen-demenz","status":"publish","type":"page","link":"https:\/\/tam-plenus.ch\/en\/spermidin-gegen-demenz\/","title":{"rendered":"Blog &#8211; Spermidin gegen Demenz"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"7690\" class=\"elementor elementor-7690 elementor-7039\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-58b8cfa0 e-flex e-con-boxed e-con e-parent\" data-id=\"58b8cfa0\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-38ddb4b1 elementor-widget elementor-widget-spacer\" data-id=\"38ddb4b1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2ed96073 elementor-widget elementor-widget-post-info\" data-id=\"2ed96073\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"post-info.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul class=\"elementor-inline-items elementor-icon-list-items elementor-post-info\">\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item elementor-repeater-item-c3fe21e elementor-inline-item\" itemprop=\"datePublished\">\n\t\t\t\t\t\t<a href=\"https:\/\/tam-plenus.ch\/en\/2023\/09\/25\/\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-calendar\"><\/i>\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text elementor-post-info__item elementor-post-info__item--type-date\">\n\t\t\t\t\t\t\t\t\t\t<time>September 25, 2023<\/time>\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t<\/li>\n\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-52a9511f elementor-widget elementor-widget-heading\" data-id=\"52a9511f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">AUTHOR: Assoc. Prof. Dr. Simon Sedej, PhD <\/br>\nMedical University of Graz<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1606f0fa elementor-widget elementor-widget-heading\" data-id=\"1606f0fa\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Spermidine against dementia<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b29070a elementor-widget elementor-widget-text-editor\" data-id=\"b29070a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Spermidine is considered a promising natural and endogenous substance for reducing the risk of developing dementia.<br>Further clinical studies are desirable.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3181e39 elementor-widget elementor-widget-spacer\" data-id=\"3181e39\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-cb6336e e-flex e-con-boxed e-con e-parent\" data-id=\"cb6336e\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-a2ae38c e-con-full e-flex e-con e-child\" data-id=\"a2ae38c\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7874e7e8 elementor-widget elementor-widget-text-editor\" data-id=\"7874e7e8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>In Austria, according to recent epidemiological estimates, around 115,000 to 130,000 people live with some form of dementia. As a result of increasing life expectancy, overweight, diabetes, and age-associated cardiovascular complications, the number of people at increased risk of dementia\u2014and consequently the number of those affected by dementia\u2014is continuously rising. Unless a breakthrough in prevention and therapy is achieved, various projections of population development suggest that the number of people with dementia will roughly double by the year 2050.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5384989 elementor-widget elementor-widget-text-editor\" data-id=\"5384989\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-style: inherit; font-weight: inherit; color: var( --e-global-color-text ); background-color: var(--ast-global-color-5); letter-spacing: 0.2px;\">Spermidine is a natural substance derived from amino acid metabolism, found in all living cells and organisms, and its concentration generally decreases with age. Systemic spermidine levels are maintained by three sources: dietary intake, the gut microbiome, and cellular biosynthesis (originating from the amino acid arginine).<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ec3d990 elementor-widget elementor-widget-text-editor\" data-id=\"ec3d990\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-style: inherit; font-weight: inherit; color: var( --e-global-color-text ); background-color: var(--ast-global-color-5); letter-spacing: 0.2px;\">Spermidine has been described as a so-called caloric restriction mimetic, meaning that external supplementation mimics certain aspects and cellular processes of fasting. An important cellular process initiated in this context is so-called autophagy (from the Greek for \u201cself-eating\u201d), a kind of molecular recycling mechanism that is activated during periods of nutrient deprivation to overcome energy crises. During autophagy, cellular components that are dispensable for the immediate function of the cell\u2014such as fats, mitochondria, and aggregated proteins\u2014are digested in the lysosome and broken down into reusable units. This process also breaks down cellular \u201cwaste dumps\u201d (such as aggregated proteins or defective mitochondria), which in aging can contribute to neurodegeneration and other (cellular) dysfunctions.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-566d4c0 elementor-widget elementor-widget-image\" data-id=\"566d4c0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"504\" height=\"184\" src=\"https:\/\/tam-plenus.ch\/wp-content\/uploads\/2023\/09\/grafik-demenz-blog.jpg\" class=\"attachment-large size-large wp-image-7052\" alt=\"Grafik Demenz. Klinische Intervention.\" srcset=\"https:\/\/tam-plenus.ch\/wp-content\/uploads\/2023\/09\/grafik-demenz-blog.jpg 504w, https:\/\/tam-plenus.ch\/wp-content\/uploads\/2023\/09\/grafik-demenz-blog-300x110.jpg 300w\" sizes=\"(max-width: 504px) 100vw, 504px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-98c1fbd elementor-widget elementor-widget-text-editor\" data-id=\"98c1fbd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Spermidine Supplementation Delays Cardiac Aging<\/strong><br>Research as early as 2016 demonstrated a cardioprotective effect of a spermidine-rich diet (Eisenberg et al., 2016; Cardioprotection and lifespan extension by the natural polyamine spermidine. Nature Medicine, 22(12): 1428\u20131438. doi: 10.1038\/nm.4222). In animal models, spermidine supplementation (added to drinking water) was shown to delay cardiac aging and reduce salt-induced hypertension. Supporting data were also observed in an epidemiological human cohort study: higher dietary spermidine correlated directly with a lower risk of heart failure, fewer cardiovascular diseases, and a reduced incidence of death due to heart failure (Bruneck Study).<\/p><p>Building on these age-protective and autophagy-promoting properties of spermidine, the potential neuroprotective effects of spermidine have come into focus in recent years of spermidine research. Sigrist and colleagues demonstrated in a groundbreaking publication that <em>(Gupta et al., 2013; Restoring polyamines protects from age-induced memory impairment <\/em><em>in an autophagy-dependent manner).<\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-626b4b1 elementor-widget elementor-widget-text-editor\" data-id=\"626b4b1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><\/p>\n<h5 style=\"padding-left: 40px;\">Spermidine is a<br>natural substance<br>derived from<br>amino acid metabolism, <br>found in all living<br>cells and organisms.<\/h5>\n<p><em>Nature Neuroscience. 16(10): 1453\u2013<\/em><em>1460. doi: 10.1038\/nn.3512.),<\/em> that in fruit flies, an age-related decline in cognitive performance\u2014similar to that observed in humans\u2014can be halted through spermidine supplementation. This improvement in memory function through spermidine was accompanied by an autophagy-mediated reduction of aggregated proteins in the brains of the flies. Autophagy was necessary for the spermidine-induced improvement of cognitive function in aged flies.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-dfffbf4 elementor-widget elementor-widget-text-editor\" data-id=\"dfffbf4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Reduction of Neuroinflammation<\/strong><br>A number of subsequent publications have confirmed these findings in rodents. For example, Filfan and colleagues showed that lifelong supplementation of rats with spermidine reduced neuroinflammation, while various aspects of learning, such as exploratory behavior, were improved. <em>(Filfan et al., 2020; Long-term treatment with spermidine increases health span of middle-aged Sprague-Dawley male rats. GeroScience. doi: 10.1007\/ s11357-020-00173-5).<\/em> Another study demonstrated in a genetically fast-aging mouse cohort that spermidine supplementation minimized brain aging as well as behavioral aspects of aging. <em>(Xu et al.; 2020; Spermidine and spermine delay brain aging by inducing autophagy in SAMP8 mice. Aging. doi: 10.18632\/aging.103035).<\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-fab00d2 e-con-full e-flex e-con e-child\" data-id=\"fab00d2\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2ee9c00 elementor-widget elementor-widget-text-editor\" data-id=\"2ee9c00\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-style: inherit; font-weight: inherit; color: var( --e-global-color-text ); background-color: var(--ast-global-color-5); letter-spacing: 0.2px;\">De Risi and colleagues were able to show that transgenic mice suffering from mild dementia exhibited improved memory function and a lower amount of proteotoxic aggregates in the brain when fed spermidine<\/span><em style=\"font-weight: inherit; color: var( --e-global-color-text ); background-color: var(--ast-global-color-5); letter-spacing: 0.2px;\"> (De Risi et al.; 2019; Mechanisms by which autophagy regulates memory capacity in ageing. Aging Cell. n\/a(n\/a): e13189. doi: 10.1111\/acel.13189).<\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-10c35c1 elementor-widget elementor-widget-image\" data-id=\"10c35c1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"563\" height=\"591\" src=\"https:\/\/tam-plenus.ch\/wp-content\/uploads\/2023\/09\/demenz-blog-symbolbild.jpg\" class=\"attachment-large size-large wp-image-7067\" alt=\"Demenz Blog - Neuroinflammation verringert\" srcset=\"https:\/\/tam-plenus.ch\/wp-content\/uploads\/2023\/09\/demenz-blog-symbolbild.jpg 563w, https:\/\/tam-plenus.ch\/wp-content\/uploads\/2023\/09\/demenz-blog-symbolbild-286x300.jpg 286w\" sizes=\"(max-width: 563px) 100vw, 563px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d7c46d4 elementor-widget elementor-widget-text-editor\" data-id=\"d7c46d4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Recently, Madeo, Sigrist, and Eisenberg demonstrated in two publications that dietary spermidine actually reaches the brains of mice, thereby crossing the blood-brain barrier. <em>(Schroeder et al.; 2021; Dietary spermidine improves cognitive function. Cell Reports. 35(2): 108985. doi: 10.1016\/j. celrep.2021.108985; Liang Y, et al., 2021; eIF5A hypusination, boosted by dietary spermidine, protects from premature brain aging and mitochondrial dysfunction. Cell Reports. 35(2): 108941. doi: 10.1016\/j.celrep. 2021.108941).<\/em> Here too, the mice exhibited improved memory function in old age, along with modification of a key protein translation factor (EIF5A in the hippocampus, a critical node between short-term and long-term memory). This biochemical modification (also known as hypusination) as well as mitochondrial autophagy (mitophagy) were shown to be causal for the improvement of memory function by spermidine in aging flies.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-75053f5 elementor-widget elementor-widget-text-editor\" data-id=\"75053f5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h5 style=\"padding-left: 40px;\"><span style=\"color: #ff0000;\">The dementia-protective<br><\/span><span style=\"color: #ff0000;\">potential of spermidine<\/span><br><span style=\"color: #ff0000;\">was recently demonstrated by<\/span><br><span style=\"color: #ff0000;\">another<\/span><br><span style=\"color: #ff0000;\">confirmed by another pilot study.<\/span><\/h5><p><strong><br>Evidence in humans<\/strong><br>The now very solid preclinical evidence for spermidine as a neuroprotective molecule during ageing is being joined by more and more human studies. In an epidemiological study, Stefan Kiechl from the Medical University of Innsbruck, together with Madeo and Eisenberg, demonstrated a correlation between the amount of dietary spermidine intake and memory function. A randomized clinical pilot study conducted by Charit\u00e9 in Berlin (the preSMARTAGE study) also demonstrated an improvement in memory function through spermidine supplementation. Three months after taking a spermidine-rich wheat germ extract, participants who reported a self-perceived, but not yet clinically manifest, decline in memory function showed an increased score on the so-called \u201cmnemonic discrimination test.\u201d This is a cognitive performance test that assesses the ability to discriminate and recognize similar images <em>(Wirth et al., 2018; The effect of spermidine on memory performance in older adults at risk for dementia: A randomized controlled trial. Cortex, 109: 181\u2013188. doi: 10.1016\/j.cortex.2018.09.014). <\/em>Higher spermidine intake was correlated with increased hippocampal volume and greater cortical thickness (Schwarz et al., 2020; Spermidine intake is associated with cortical thickness and hippocampal volume in older adults. NeuroImage, 221: 117132. doi: 10.1016\/j.neuroimage.2020.117132). The dementia-protective potential of spermidine was recently confirmed by a further three-month multicenter pilot study in Styria\/Austria <em>(Pekar et al., 2021; The positive effect of spermidine in older adults suffering from dementia. Wiener Klinische Wochenschrift. 133(9): 484-491. doi: 10.1007\/s00508-020-01758-y).<\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-acbc387 elementor-widget elementor-widget-text-editor\" data-id=\"acbc387\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Based on these scientific findings, spermidine is considered a promising natural and endogenous substance for reducing the risk of developing dementia and should be further investigated in larger multicenter clinical studies.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-019f6c9 e-flex e-con-boxed e-con e-parent\" data-id=\"019f6c9\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d7f13a5 elementor-widget elementor-widget-spacer\" data-id=\"d7f13a5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-75334fa e-flex e-con-boxed e-con e-parent\" data-id=\"75334fa\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c1dde60 elementor-widget elementor-widget-text-editor\" data-id=\"c1dde60\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h4>More articles \u00bb<\/h4>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-eb2470c elementor-align-right elementor-widget elementor-widget-button\" data-id=\"eb2470c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/tam-plenus.ch\/en\/blog-archiv\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Blog overview<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>AUTHOR: Assoc. Prof. Dr. Simon Sedej, PhD Medical University of Graz Spermidine against dementia Spermidine is considered a promising natural and endogenous substance for reducing the risk of developing dementia.Further clinical studies are desirable. In Austria, according to recent epidemiological estimates, around 115,000 to 130,000 people live with some form of dementia. As a result 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