{"id":20972,"date":"2025-03-27T09:34:51","date_gmt":"2025-03-27T08:34:51","guid":{"rendered":"https:\/\/tam-plenus.ch\/blog-eine-sache-des-herzens\/"},"modified":"2025-08-15T18:16:39","modified_gmt":"2025-08-15T16:16:39","slug":"blog-eine-sache-des-herzens","status":"publish","type":"page","link":"https:\/\/tam-plenus.ch\/en\/blog-eine-sache-des-herzens\/","title":{"rendered":"Blog &#8211; A matter of the heart"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"20972\" class=\"elementor elementor-20972 elementor-20807\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d69941c e-flex e-con-boxed e-con e-parent\" data-id=\"d69941c\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-3039518 e-con-full e-flex e-con e-child\" data-id=\"3039518\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7768d5b elementor-widget elementor-widget-post-info\" data-id=\"7768d5b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"post-info.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul class=\"elementor-inline-items elementor-icon-list-items elementor-post-info\">\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item elementor-repeater-item-c3fe21e elementor-inline-item\" itemprop=\"datePublished\">\n\t\t\t\t\t\t<a href=\"https:\/\/tam-plenus.ch\/en\/2025\/03\/27\/\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-calendar\"><\/i>\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text elementor-post-info__item elementor-post-info__item--type-date\">\n\t\t\t\t\t\t\t\t\t\t<time>March 27, 2025<\/time>\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t<\/li>\n\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-76a6c37 elementor-widget elementor-widget-spacer\" data-id=\"76a6c37\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f913e23 elementor-widget elementor-widget-heading\" data-id=\"f913e23\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">A Matter of the Heart: <br>Spermidine\u2019s Protective Role <br>in Cardiovascular Health<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5e6b755 e-con-full e-flex e-con e-child\" data-id=\"5e6b755\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-339628c elementor-widget elementor-widget-image\" data-id=\"339628c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"850\" height=\"510\" src=\"https:\/\/tam-plenus.ch\/wp-content\/uploads\/2025\/03\/Heart_header.jpg\" class=\"attachment-large size-large wp-image-20812\" alt=\"\" srcset=\"https:\/\/tam-plenus.ch\/wp-content\/uploads\/2025\/03\/Heart_header.jpg 850w, https:\/\/tam-plenus.ch\/wp-content\/uploads\/2025\/03\/Heart_header-300x180.jpg 300w, https:\/\/tam-plenus.ch\/wp-content\/uploads\/2025\/03\/Heart_header-768x461.jpg 768w, https:\/\/tam-plenus.ch\/wp-content\/uploads\/2025\/03\/Heart_header-600x360.jpg 600w\" sizes=\"(max-width: 850px) 100vw, 850px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d040583 e-flex e-con-boxed e-con e-parent\" data-id=\"d040583\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1606abf elementor-widget elementor-widget-spacer\" data-id=\"1606abf\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ae27366 elementor-widget elementor-widget-text-editor\" data-id=\"ae27366\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Spermidine is gaining recognition as a powerful bioactive compound for supporting cardiovascular health and longevity. As cardiovascular disease remains the leading cause of death worldwide, scientists are exploring novel, naturally occurring compounds that can protect the heart and extend lifespan. Spermidine\u2014a polyamine found in many fruits, vegetables, whole grains, and even produced endogenously\u2014is emerging as a promising candidate. Research spanning animal models and human studies has highlighted its role in promoting heart health, reducing inflammation, extending lifespan, and improving overall cardiovascular function through mechanisms such as enhanced autophagy and improved mitochondrial performance. In this review, we bring together findings from several pivotal studies to help you understand the many benefits that spermidine offers for both cardiovascular health and aging.    <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c322348 elementor-widget elementor-widget-spacer\" data-id=\"c322348\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3be528b elementor-widget elementor-widget-text-editor\" data-id=\"3be528b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Extending lifespan and protecting the heart<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-db399da elementor-widget elementor-widget-text-editor\" data-id=\"db399da\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>One of the landmark pieces of research comes from a 2016 study by Eisenberg et al. in Nature Medicine. In this study, researchers demonstrated that oral supplementation with spermidine not only extended the lifespan of mice but also provided significant cardioprotective benefits. Aging is commonly associated with cardiac hypertrophic remodeling, a structural and functional transformation of the heart characterized by an increase in cardiomyocyte (heart muscle cell) size and thickening of the heart walls. This process is often accompanied by a gradual decline in left ventricular diastolic function (how the heart relaxes and fills with blood after it contracts), leading to reduced cardiac efficiency and stiffness.     <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d3e3d25 elementor-widget elementor-widget-text-editor\" data-id=\"d3e3d25\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tIn this study, spermidine supplementation was shown to reduce cardiac hypertrophy, preserve diastolic function, and enhance key cellular processes such as autophagy, mitophagy, and mitochondrial respiration. It also lowered the age-dependent rise in plasma levels of the pro-inflammatory cytokine tumor necrosis factor-\u03b1 (TNF\u03b1), which contributes to chronic inflammation and is elevated in heart failure patients. Additionally, supplementation led to a decrease in blood pressure and an increase in arginine bioavailability, potentially supporting nitric oxide (NO) production. NO acts as a vasodilator, meaning it relaxes and widens blood vessels, improving blood flow and reducing strain on the heart. NO is synthesized from arginine, which is also a precursor of spermidine. By supplementing with spermidine, arginine thus becomes more bioavailable for NO biosynthesis, likely increasing its production and the observed decrease in hypertension. Spermidine supplementation also increased titin phosphorylation (titin is a large protein that helps muscle cells stretch, like an elastic band in the muscle fibers), which enhances cardiomyocyte elasticity and reduces myocardial stiffness. This effect is likely mediated through increased NO production and activation of PKG, a key kinase that phosphorylates titin. By preserving titin function and reducing TNF\u03b1-driven inflammation, spermidine helps maintain diastolic heart properties, which are often impaired in heart failure.        \t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d4992f9 elementor-widget elementor-widget-text-editor\" data-id=\"d4992f9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tImportantly, the study revealed that these benefits depend on functional autophagy, as autophagy-deficient mice did not experience the same improvements. Similar benefits were observed in hypertension rat models, and human epidemiological data suggested that higher dietary spermidine intake is associated with lower blood pressure and reduced cardiovascular disease (CVD) incidence. \t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6e8efb9 elementor-widget elementor-widget-image\" data-id=\"6e8efb9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1024\" height=\"678\" src=\"https:\/\/tam-plenus.ch\/wp-content\/uploads\/2025\/03\/Spermidine_heart_grafik-1024x678.jpg\" class=\"attachment-large size-large wp-image-20814\" alt=\"\" srcset=\"https:\/\/tam-plenus.ch\/wp-content\/uploads\/2025\/03\/Spermidine_heart_grafik-1024x678.jpg 1024w, https:\/\/tam-plenus.ch\/wp-content\/uploads\/2025\/03\/Spermidine_heart_grafik-300x199.jpg 300w, https:\/\/tam-plenus.ch\/wp-content\/uploads\/2025\/03\/Spermidine_heart_grafik-768x509.jpg 768w, https:\/\/tam-plenus.ch\/wp-content\/uploads\/2025\/03\/Spermidine_heart_grafik-600x397.jpg 600w, https:\/\/tam-plenus.ch\/wp-content\/uploads\/2025\/03\/Spermidine_heart_grafik.jpg 1134w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cb9882f elementor-widget elementor-widget-text-editor\" data-id=\"cb9882f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p> <b>Spermidine\u2019s role in cardioprotection<br><\/b>Spermidine provides overall protection to the heart by reducing oxidative stress, inflammation, and cellular damage.<br>Spermidine supplementation (i) promotes autophagy and mitophagy in cardiomyocytes; ii) improves mitochondrial volume and function; (iii) reduces chronic inflammation (circulating TNF\u03b1 levels); (iv) improves systemic arginine bioavailability that may favor the production of the vasodilator nitric oxide (NO), and thus decrease systemic blood pressure; (v) decreases left ventricle hypertrophy; and (vi) increases titin phosphorylation which improves the mechano-elastical properties of cardiomyocytes. Cardiomyocyte: heart muscle cells that contract to pump blood. Blood vessel: includes arteries and veins, which transport blood throughout the body. Titin: a spring-like protein in muscle cells that ensures smooth stretching and contracting when it\u2019s properly phosphorylated. Arginine: an amino acid precursor to NO and spermidine. Adapted from Eisenberg et al., 2017. \u00a9 2025 Melissa Cano. All rights reserved.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a424686 elementor-widget elementor-widget-spacer\" data-id=\"a424686\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-94e5616 elementor-widget elementor-widget-text-editor\" data-id=\"94e5616\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Dietary polyamines and cardiovascular mortality<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d034984 elementor-widget elementor-widget-text-editor\" data-id=\"d034984\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Before these cellular insights, a 2012 study published in the Global Journal of Health Science examined the relationship between dietary polyamines (including spermidine and its relative, spermine) and CVD mortality across 48 European and Western countries. Using food supply data and polyamine concentrations in various foods, researchers found that higher dietary intake of these polyamines was linked to lower rates of cardiovascular death. This large-scale analysis also noted that factors like higher GDP and increased consumption of fruits, vegetables, nuts, and beans were associated with better cardiovascular outcomes\u2014while smoking and whole milk consumption had the opposite effect.  <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-418c4e4 elementor-widget elementor-widget-text-editor\" data-id=\"418c4e4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tBuilding on these findings, the Bruneck Study, a 2018 prospective cohort study in The American Journal of Clinical Nutrition, tracked 829 participants aged 45\u201384 over 20 years in the town of Bruneck, Italy. The study reported that individuals with higher dietary spermidine intake experienced significantly lower all-cause mortality, suggesting that spermidine-rich diets may contribute to increased longevity. Similarly, a 2022 study published in Frontiers in Public Health analyzed data from the U.S. National Health and Nutrition Examination Survey (NHANES, 23,894 participants) and found that higher dietary spermidine intake was associated with a reduced risk of both CVD and all-cause mortality. Notably, spermidine from vegetables, cereals, legumes, nuts, and cheese demonstrated significant protective effects, reinforcing the role of dietary factors in disease prevention and cardiovascular health.    \t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-667329a elementor-widget elementor-widget-text-editor\" data-id=\"667329a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tA 2024 study in Nutrients utilized data from the UK Biobank (184,732 participants) to analyze the association between dietary polyamines and cardiovascular risk. The study found that moderate spermidine intake was linked to lower all-cause mortality and reduced CVD incidence. Another 2024 study in Nutrition used Mendelian randomization (a research method in epidemiology that mimics a randomized controlled trial using genetic data) to confirm a causal relationship between higher spermidine levels and reduced hypertension, reduced blood glucose levels, improved lipid profiles, and lower CVD risk, further supporting spermidine\u2019s potential as a dietary intervention for cardiovascular health.  \t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3bd4523 elementor-widget elementor-widget-spacer\" data-id=\"3bd4523\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cdef024 elementor-widget elementor-widget-text-editor\" data-id=\"cdef024\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>A closer look in the heart<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-44e9b4c elementor-widget elementor-widget-text-editor\" data-id=\"44e9b4c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Spermidine and aortic health<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-94ec7b5 elementor-widget elementor-widget-text-editor\" data-id=\"94ec7b5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tIn 2016, a study published in Atherosclerosis investigated spermidine\u2019s effects on atherosclerotic plaque progression (the gradual build up of fats and others substances narrowing arteries and leading to CVD) in mice. The researchers found that while spermidine did not alter the size or cellular composition of plaques, it significantly reduced lipid accumulation and necrotic core formation (the buildup of dead cells, oxidized fats, and cellular debris inside a plaque). These benefits were attributed to spermidine\u2019s ability to induce autophagy in vascular smooth muscle cells (VSMCs, which control the diameter of blood vessels), facilitating cholesterol efflux and stabilizing plaques. This study highlighted spermidine\u2019s potential as a therapeutic agent for preventing CVD by targeting plaque instability. Building on these findings, a 2020 study in Aging Cell demonstrated that spermidine reduces vascular calcification (buildup of calcium leading to stiffness) in both rat and human VSMCs under osteogenic conditions by upregulating SIRT1, a central NAD+-dependent deacetylase that modulates numerous physiological processes by deacetylating target proteins and regulating gene expression. This suggests that spermidine could also help prevent arterial stiffness and vascular calcification, common issues in aging and chronic kidney disease. Together, these studies underscore spermidine\u2019s dual role in combating atherosclerosis and vascular calcification, making it a promising candidate for cardiovascular health.      \t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1b7821f elementor-widget elementor-widget-spacer\" data-id=\"1b7821f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c4ad35c elementor-widget elementor-widget-text-editor\" data-id=\"c4ad35c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Peripheral artery disease and autophagy activation<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3b90171 elementor-widget elementor-widget-text-editor\" data-id=\"3b90171\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>A 2022 pilot study in Antioxidant examined a mixture of autophagy activators, including spermidine, in patients with peripheral artery disease (PAD, a specific type of atherosclerosis which occurs in the legs). After 60 days, patients receiving the mixture experienced a 91% increase in maximal walking distance, alongside improvements in oxidative stress markers and autophagic activity. These results indicate spermidine\u2019s potential in improving vascular function and reducing oxidative stress in PAD patients.  <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-392d8ac elementor-widget elementor-widget-spacer\" data-id=\"392d8ac\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-526d629 elementor-widget elementor-widget-text-editor\" data-id=\"526d629\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Prevention of aortic aneurysms<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b0959c9 elementor-widget elementor-widget-text-editor\" data-id=\"b0959c9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>A 2020 study in Journal of the American Heart Association investigated spermidine\u2019s effects on experimental abdominal aortic aneurysms (AAAs, bulges in the aorta that can lead to its rupture) in mice. Spermidine treatment preserved aortic structural integrity, reduced inflammation, and increased autophagy-related proteins, suggesting its promise in preventing aneurysm progression. <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5c4e829 elementor-widget elementor-widget-spacer\" data-id=\"5c4e829\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5189719 elementor-widget elementor-widget-text-editor\" data-id=\"5189719\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<strong>Spermidine and mitochondrial function<\/strong>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1008d91 elementor-widget elementor-widget-text-editor\" data-id=\"1008d91\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Several studies have explored spermidine\u2019s role in mitochondrial health. A 2020 study in Aging found that spermidine supplementation in aged rats improved mitochondrial biogenesis by activating the SIRT1\/PGC-1\u03b1 signaling pathway (PGC-1\u03b1 is a master regulator of mitochondrial biogenesis), preserving myocardial structure and function. A 2021 study in Journal of Anatomy similarly demonstrated that spermidine supplementation increased mitochondrial numbers in aged mice and improved their structural alignment, suggesting that spermidine helps maintain mitochondrial integrity in aging hearts.  <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c585692 elementor-widget elementor-widget-spacer\" data-id=\"c585692\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-533e562 elementor-widget elementor-widget-text-editor\" data-id=\"533e562\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>The role of spermidine in arterial aging and endothelial function<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0d6896b elementor-widget elementor-widget-text-editor\" data-id=\"0d6896b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>A 2013 study in Mechanism of Ageing and Development showed that spermidine supplementation reduced arterial stiffness in aged mice (the loss of elasticity in the arteries leading to CVD, primarily caused by aging). It also improved endothelial function (the ability of the thin layer of cells lining the blood vessels to properly control blood flow) by enhancing autophagy and increasing NO production. A 2023 study in Scientific Reports further supported these findings, showing that spermidine improved angiogenesis (the development of new blood vessels) and neovascularization in ischemic limbs (the development of small blood vessels to compensate for impaired blood flow) of aged mice by enhancing autophagy and mitochondrial function. Similarly, a 2017 study in Oncotarget reported that both spermidine and its relative spermine reversed age-related myocardial alterations in rats, reduced fibrosis (the overgrowth of scar tissue that can affect organ function), and decreased apoptosis (cell death), further suggesting that polyamines can modulate key pathways involved in cardiac deterioration.   <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-73d1337 elementor-widget elementor-widget-spacer\" data-id=\"73d1337\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3c3ef78 elementor-widget elementor-widget-text-editor\" data-id=\"3c3ef78\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<strong>The gut-heart connection<\/strong>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2ae709d elementor-widget elementor-widget-text-editor\" data-id=\"2ae709d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tBeyond direct cardiac effects, spermidine appears to influence cardiovascular health via the gut microbiota. A 2020 study in Biological &amp; Pharmaceutical Bulletin developed an innovative hybrid putrescine biosynthesis system using Bifidobacterium animalis ssp. lactis and arginine to boost polyamine production in the gut. A clinical trial involving a specially formulated yogurt showed improved vascular endothelial function and elevated blood spermidine levels, indicating a reduced risk of atherosclerosis. Additionally, a 2019 review in the Journal of Molecular and Cellular Cardiology highlighted how polyamines synthesized by both our cells and gut bacteria contribute to improved cardiomyocyte function, enhanced NO bioavailability, and reduced systemic inflammation\u2014factors critical in preventing aortopathy in patients with bicuspid and tricuspid aortic valves. Further supporting this gut-heart axis, a 2021 study in Frontiers in Cardiovascular Medicine demonstrated that spermidine supplementation improved cardiac function in heart failure mice while modulating gut microbiota composition, suggesting a potential mechanistic link between gut-derived polyamines and cardiovascular health.     \t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d3dc41d elementor-widget elementor-widget-spacer\" data-id=\"d3dc41d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-df2c5c9 elementor-widget elementor-widget-text-editor\" data-id=\"df2c5c9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Mechanisms underlying spermidine\u2019s cardioprotective effects<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a21f9d1 elementor-widget elementor-widget-text-editor\" data-id=\"a21f9d1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Across these studies, several recurring mechanisms emerge:<\/p><ul><li><strong>Enhanced autophagy and mitophagy:<\/strong> Spermidine consistently stimulates cellular recycling processes, which help clear damaged organelles and proteins, leading to improved cell survival and function.<\/li><li><strong>Improved mitochondrial function:<\/strong> Many studies show that spermidine restores mitochondrial biogenesis and quality, ensuring that cardiomyocytes maintain their energy supply and structural integrity.<\/li><li><strong>Anti-inflammatory and antioxidant effects: <\/strong>By reducing oxidative stress and systemic inflammation, spermidine contributes to healthier blood vessels and less plaque instability.<\/li><li><strong>Gut microbiota interactions: <\/strong>The modulation of gut bacterial metabolism can increase endogenous spermidine production, offering an additional layer of cardiovascular protection.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5639911 elementor-widget elementor-widget-text-editor\" data-id=\"5639911\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Conclusion : you can protect your heart with spermidine<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7897db5 elementor-widget elementor-widget-text-editor\" data-id=\"7897db5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Spermidine has emerged as a powerful and versatile nutraceutical with significant potential to support cardiovascular health and promote longevity. Through its ability to enhance autophagy, improve mitochondrial function, reduce oxidative stress, and modulate inflammation, spermidine addresses multiple hallmarks of CVD. Studies spanning animal models and human populations have demonstrated its cardioprotective effects, including reducing cardiac hypertrophy, stabilizing atherosclerotic plaques, preventing vascular calcification, and improving endothelial function. Furthermore, spermidine\u2019s interaction with the gut microbiota adds another layer of complexity to its benefits, suggesting a holistic approach to cardiovascular health.   <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ffaff11 elementor-widget elementor-widget-text-editor\" data-id=\"ffaff11\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tThe evidence is compelling: spermidine-rich diets are associated with lower blood pressure, reduced cardiovascular mortality, and increased lifespan. Clinical trials and mechanistic studies continue to uncover new ways in which spermidine can protect the heart, from improving peripheral artery disease symptoms to preventing aortic aneurysms. As research progresses, spermidine\u2019s role as a dietary intervention for cardiovascular health becomes increasingly clear.  \t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-33f3311 elementor-widget elementor-widget-text-editor\" data-id=\"33f3311\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>For those looking to support their heart health naturally, incorporating spermidine-rich foods\u2014such as whole grains, legumes, aged cheeses, and mushrooms\u2014into the diet may offer a simple yet effective strategy. Additionally, <b>spermidine supplementation could provide a targeted approach for individuals at risk of CVD or those seeking to optimize their longevity.<\/b> While further clinical trials are needed to fully establish its therapeutic potential, the current body of evidence positions spermidine as a promising candidate for the prevention and management of CVD. <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bc59bc8 elementor-widget elementor-widget-text-editor\" data-id=\"bc59bc8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Tackling this global health challenge demands a multifaceted approach, including public health interventions, lifestyle changes, and improved healthcare access. In this context, spermidine emerges as a natural, science-backed ally, offering a promising strategy to support heart health and enhance both lifespan and healthspan, helping to combat the growing threat of heart disease. <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3a74dd6 elementor-widget elementor-widget-spacer\" data-id=\"3a74dd6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-53e3f1c e-flex e-con-boxed e-con e-parent\" data-id=\"53e3f1c\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-393bab5 e-con-full e-flex e-con e-child\" data-id=\"393bab5\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4b395c8 elementor-widget elementor-widget-text-editor\" data-id=\"4b395c8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>References:<\/strong><\/p><p><a href=\"https:\/\/www.nature.com\/articles\/nm.4222\" target=\"_blank\" rel=\"noopener\"><strong>[1] Eisenberg T et al.<\/strong> Cardioprotection and lifespan extension by the natural <span data-highlight=\"spermidine\">polyamine spermidine. <\/span>Nat Med. 2016 Dec;22(12):1428-1438. doi: 10.1038\/nm.4222. Epub 2016 Nov 14. PMID: 27841876; PMCID: PMC5806691.    <\/a><\/p><p><a href=\"https:\/\/www.ccsenet.org\/journal\/index.php\/gjhs\/article\/view\/21003\" target=\"_blank\" rel=\"noopener\"><strong>[2] Soda K et al. <\/strong>Food polyamine and cardiovascular disease&#8211;an epidemiological study. Glob J Health Sci. 2012 Sep 28;4(6):170-8. doi: 10.5539\/gjhs.v4n6p170. PMID: 23121753; PMCID: PMC4776963.   <\/a><\/p><p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0002916522029306?via%3Dihub\" target=\"_blank\" rel=\"noopener\"><strong>[3] Kiechl S et al. <\/strong>Higher <span data-highlight=\"spermidine\">spermidine intake<\/span> is linked to lower mortality: a prospective population-based study. Am J Clin Nutr. 2018 Aug 1;108(2):371-380. doi: 10.1093\/ajcn\/nqy102. 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PMID: 36139910; PMCID: PMC9495993.  <\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a5d44f9 e-con-full e-flex e-con e-child\" data-id=\"a5d44f9\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-634426b elementor-widget elementor-widget-text-editor\" data-id=\"634426b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p> <\/p><p><a href=\"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.119.014757?rfr_dat=cr_pub++0pubmed&amp;url_ver=Z39.88-2003&amp;rfr_id=ori%3Arid%3Acrossref.org\" target=\"_blank\" rel=\"noopener\"><strong>[10] Liu S et al. <\/strong><span data-highlight=\"spermidine\">Spermidine <\/span>Suppresses Development of Experimental Abdominal Aortic Aneurysms. J Am Heart Assoc. 2020 Apr 21;9(8):e014757. doi: 10.1161\/JAHA.119.014757. Epub 2020 Apr 19. PMID: 32308093; PMCID: PMC7428527.     <\/a><\/p><p><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1111\/joa.13618\" target=\"_blank\" rel=\"noopener\"><strong>[12] Messerer J et al. <\/strong><span data-highlight=\"spermidine\">Spermidine <\/span>supplementation influences mitochondrial number and morphology in the heart of aged mice. J Anat. 2023 Jan;242(1):91-101. doi: 10.1111\/joa.13618. Epub 2021 Dec 27. PMID: 34958481; PMCID: PMC9773166.    <\/a><\/p><p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S004763741300050X?via%3Dihub\" target=\"_blank\" rel=\"noopener\"><strong>[13] LaRocca TJ et al. <\/strong>The <span data-highlight=\"autophagy\">autophagy <\/span>enhancer <span data-highlight=\"spermidine\">spermidine reverses <\/span>arterial aging. Mech <span data-highlight=\"aging\">Ageing <\/span>Dev. 2013 Jul-Aug;134(7-8):314-20. doi: 10.1016\/j.mad.2013.04.004. Epub 2013 Apr 20. PMID: 23612189; PMCID: PMC3700669.    <\/a><\/p><p><a href=\"https:\/\/www.nature.com\/articles\/s41598-023-35447-3\" target=\"_blank\" rel=\"noopener\"><strong>[14] Ueno D et al. <\/strong><span data-highlight=\"spermidine\">Spermidine i<\/span>mproves angiogenic capacity of senescent endothelial cells, and enhances ischemia-induced neovascularization in aged mice. Sci Rep. 2023 May 23;13(1):8338. doi: 10.1038\/s41598-023-35447-3. PMID: 37221395; PMCID: PMC10205711.  <\/a><\/p><p><a href=\"https:\/\/www.oncotarget.com\/article\/18334\/text\/\" target=\"_blank\" rel=\"noopener\"><strong>[15] Zhang H et al.<\/strong> Spermine and <span data-highlight=\"spermidine\">spermicides<\/span> reversed age-related cardiac deterioration in rats. Oncotarget. May 31, 2017:98(39):64793-64808. doi: 10.18632\/oncoto.18334. PMID: 29029392; PMCID: PMC5630292.    <\/a><\/p><p><a href=\"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/43\/2\/43_b19-00855\/_article\" target=\"_blank\" rel=\"noopener\">[<strong>16] Matsumoto M.<\/strong> Prevention of atherosclerosis by the induction of microbial polyamine production in the intestinal lumen. Biol Pharm Bull. 2020;43(2):221-229. doi: 10.1248\/bpb.b19-00855. PMID: 32009110    <\/a><\/p><p><a href=\"https:\/\/www.jmcc-online.com\/article\/S0022-2828(19)30016-1\/abstract\" target=\"_blank\" rel=\"noopener\"><strong>[17] Forte A et al.<\/strong> Polyamine und Mikrobiota in Bicuspid und Trikuspid-Aortenklappenaortopathie. J Mol Cell Cardiol 2019 Apr;129:179-187. doi: 10.1016\/j.jjmcc.2019.02.014. Epub 2019 28. PMID: 30825483.   <\/a><\/p><p><a href=\"https:\/\/www.frontiersin.org\/journals\/cardiovascular-medicine\/articles\/10.3389\/fcvm.2021.765591\/full\" target=\"_blank\" rel=\"noopener\"><strong>[18] Chen Y et al. <\/strong><span data-highlight=\"spermidine\">Spermidine<\/span> affects cardiac function in heart failure twitters through influence of gut microbiota and cardiac galectin-3. Front Cardiovascular Med. 2021 Dec 2;8:765591. doi: 10.3389\/fcvm.2021.765591. PMID: 34926616; PMCID: PMC8674475.    <\/a><\/p><p><a href=\"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/15548627.2017.1280225?scroll=top&amp;needAccess=true\"><strong>[19] Eisenberg T et al. <\/strong><span data-highlight=\"spermidine\">Dietary spermidine<\/span> for lowering high blood pressure. <span data-highlight=\"autophagy\">Autophagy<\/span>.<br>2017 Apr 3;13(4):767-769. doi: 10.1080\/15548627.2017.1280225. Epub 2017 Jan 24.<br>PMID: 28118075; PMCID: PMC5381711.  <\/a><\/p><div class=\"metafield-rich_text_field\"> <\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-810e193 e-flex e-con-boxed e-con e-parent\" data-id=\"810e193\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8da8ca5 elementor-widget elementor-widget-spacer\" data-id=\"8da8ca5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b9a29f6 elementor-widget elementor-widget-image\" data-id=\"b9a29f6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/tam-plenus.ch\/en\/shop-seite\/\">\n\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1024\" height=\"448\" src=\"https:\/\/tam-plenus.ch\/wp-content\/uploads\/2024\/06\/spermidineLIFE-Gruppe-1024x448.jpg\" class=\"attachment-large size-large wp-image-14900\" alt=\"\" srcset=\"https:\/\/tam-plenus.ch\/wp-content\/uploads\/2024\/06\/spermidineLIFE-Gruppe-1024x448.jpg 1024w, https:\/\/tam-plenus.ch\/wp-content\/uploads\/2024\/06\/spermidineLIFE-Gruppe-300x131.jpg 300w, https:\/\/tam-plenus.ch\/wp-content\/uploads\/2024\/06\/spermidineLIFE-Gruppe-768x336.jpg 768w, https:\/\/tam-plenus.ch\/wp-content\/uploads\/2024\/06\/spermidineLIFE-Gruppe-600x262.jpg 600w, https:\/\/tam-plenus.ch\/wp-content\/uploads\/2024\/06\/spermidineLIFE-Gruppe.jpg 1096w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b762390 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"b762390\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/tam-plenus.ch\/en\/shop-seite\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Buy now<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-110a123 elementor-widget elementor-widget-spacer\" data-id=\"110a123\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3f00fe3 e-flex e-con-boxed e-con e-parent\" data-id=\"3f00fe3\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-402278d elementor-widget elementor-widget-text-editor\" data-id=\"402278d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h4>More articles \u00bb<\/h4>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f9abd82 elementor-align-right elementor-widget elementor-widget-button\" data-id=\"f9abd82\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/tam-plenus.ch\/en\/blog-archiv\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Blog overview<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>A Matter of the Heart: Spermidine\u2019s Protective Role in Cardiovascular Health Spermidine is gaining recognition as a powerful bioactive compound for supporting cardiovascular health and longevity. As cardiovascular disease remains the leading cause of death worldwide, scientists are exploring novel, naturally occurring compounds that can protect the heart and extend lifespan. Spermidine\u2014a polyamine found in [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"full-width-container","site-content-style":"unboxed","site-sidebar-style":"unboxed","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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